|
KMID : 0370220210650040331
|
|
Yakhak Hoeji
2021 Volume.65 No. 4 p.331 ~ p.334
|
|
|
Synthesis and Evaluation of Pyridazine Analogs as Potential Antidiabetic Agent
|
|
Vo Duy Viet
Park Hae-Il
|
|
|
Abstract
|
|
|
|
3,6-Disubstituted pyridazine analogs (2a and 2b) were synthesized from commercially available 3,6-dichloropyridazine in two steps. The synthesized compounds were evaluated for their GPR119 agonistic activity. Bothcompounds exhibited much stronger EC50 values than that of oleylethanolamide (OEA) and were proved to be partialagonists. These results indicate that the pyridazine ring can be used as a potential heterocycle scaffold for GPR119agonists.
|
|
|
KEYWORD
|
|
|
GPR119 agonists, Antidiabetic agents, Fragment structure, Bioequivalent, Pyridazine analogs, Lead compounds
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|